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Hanna Bielarczyk Selected Research

Acetyl Coenzyme A (Acetyl-CoA)

1/2018The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain.
3/2017Early and Late Pathomechanisms in Alzheimer's Disease: From Zinc to Amyloid-β Neurotoxicity.
4/2015Differential effects of lipopolysaccharide on energy metabolism in murine microglial N9 and cholinergic SN56 neuronal cells.
1/2015AβPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimer's Disease.
8/2014Intracellular redistribution of acetyl-CoA, the pivotal point in differential susceptibility of cholinergic neurons and glial cells to neurodegenerative signals.
8/2013Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases.
12/2010Acetyl-CoA deficit in brain mitochondria in experimental thiamine deficiency encephalopathy.
10/2010Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain.
8/2006RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level.
8/2004Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells.
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Hanna Bielarczyk Research Topics

Disease

10Neuroblastoma
01/2018 - 09/2003
8Brain Diseases (Brain Disorder)
06/2021 - 01/2010
6Alzheimer Disease (Alzheimer's Disease)
06/2021 - 12/2005
2Colonic Neoplasms (Colon Cancer)
01/2017 - 01/2016
2Colorectal Neoplasms (Colorectal Cancer)
01/2017 - 01/2016
2Neurodegenerative Diseases (Neurodegenerative Disease)
03/2015 - 08/2013
2Thiamine Deficiency
12/2010 - 10/2010
1Hypoxia (Hypoxemia)
06/2021
1Dementia (Dementias)
06/2021
1Type 2 Diabetes Mellitus (MODY)
02/2020
1Neoplasms (Cancer)
01/2016
1Memory Disorders (Memory Loss)
03/2015
1Necrosis
08/2014
1Hyperglycemia
02/2007

Drug/Important Bio-Agent (IBA)

15Cholinergic Agents (Cholinergics)IBA
06/2021 - 09/2003
11Acetyl Coenzyme A (Acetyl-CoA)IBA
01/2018 - 09/2003
5Pyruvic Acid (Pyruvate)IBA
06/2021 - 08/2006
5ZincIBA
06/2021 - 11/2007
4Acetylcholine (Acetylcholine Chloride)FDA Link
03/2015 - 08/2004
3Oxidoreductases (Dehydrogenase)IBA
06/2021 - 12/2010
3Adenosine Triphosphate (ATP)IBA
04/2015 - 02/2007
2Thiamine PyrophosphateIBA
06/2021 - 08/2013
2EnzymesIBA
06/2021 - 04/2015
2Amyloid (Amyloid Fibrils)IBA
03/2017 - 01/2015
2Fluorouracil (Carac)FDA LinkGeneric
01/2017 - 01/2016
2Tretinoin (Retinoic Acid)FDA LinkGeneric
03/2015 - 01/2005
2Amyloid beta-PeptidesIBA
08/2006 - 12/2005
1Aconitate Hydratase (Aconitase)IBA
06/2021
1bromopyruvateIBA
02/2020
1Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
02/2020
1Calcium Channel Blockers (Blockers, Calcium Channel)IBA
01/2018
1Proteins (Proteins, Gene)FDA Link
01/2016
1Toll-Like Receptor 4IBA
04/2015
1Neurotransmitter Agents (Neurotransmitter)IBA
03/2015
1Interleukin-6 (Interleukin 6)IBA
08/2014
1PyrithiamineIBA
12/2010
1Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA
10/2010
1Adenosine Diphosphate (ADP)IBA
02/2007
1AcetyltransferasesIBA
08/2006
1Trypan BlueFDA Link
08/2006
1Choline DehydrogenaseIBA
08/2006
1Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
08/2006
1CytokinesIBA
12/2005
1Interleukin-1beta (Interleukin 1 beta)IBA
12/2005
1Cyclic AMP (AMP, Cyclic)IBA
01/2005
1Nerve Growth Factor (NGF)IBA
08/2004

Therapy/Procedure

2Adjuvant Chemotherapy
01/2017 - 01/2016